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• Amal Younis#, Kanar Yassen#, Kinneret Rozales#, Tahani Kadah, Naseeb Saida, Anatoly Meller, Joyeeta Dutta Hazra, Ronit Heinrich, Flonia Levy-Adam, Shai Berlin and Reut Shalgi. Targeting FUS-ALS aggregation with Proteasome Inhibitors. bioRXiv. 2024.

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• Nadeen Akaree, Valentina Secco, Flonia Levy-Adam, Amal Younis, Serena Carra* and Reut Shalgi*. Regulation of physiological and pathological condensates by molecular chaperones. The FEBS Journal. 2024.

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• Matthias P. Mayer, Laura Blair, Gregory L. Blatch, Thiago J. Borges, Ahmed Chadli, Gabriela Chiosis, Aurélie de Thonel, Albena Dinkova-Kostova, Heath Ecroyd, Adrienne L. Edkins, Takanori Eguchi, Monika Fleshner, Kevin P. Foley, Sotirios Fragkostefanakis, Jason Gestwicki, Pierre Goloubinoff, Jennifer Heritz, Christine M. Heske, Jonathan D. Hibshman, Jenny Joutsen, Wei Li, Michael Lynes, Marc L. Mendillo, Nahid Mivechi, Fortunate Mokoena, Yuka Okusha, Veena Prahlad, Elizabeth Repasky, Sara Sannino, Federica Scalia, Reut Shalgi, Lea Sistonen, Emily Sontag, Patricija van Oosten-Hawle, Anniina Vihervaara, Anushka Wickramaratne, Shawn Xiang Yang Wang, Tawanda Zininga. Stress Biology: Complexity and Multifariousness in Health and Disease. Cell Stress and Chaperones. 2024.

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• Jaroslaw Marszalek, Paolo De Los Rio, Douglas Cyr, Matthias P. Mayer, Vasista Adupa, Claes Andréasson, Gregory L. Blatch, Janice Braun, Jeffrey L. Brodsky, Bernd Bukau, J. Paul Chapple, Charlotte Conz, Sébastien Dementin, Pierre Genevaux, Olivier Genest, Pierre Goloubinoff, Jason Gestwicki, Colin M. Hammond, Justin K. Hines, Koji Ishikawa, Lukasz Joachimiak, Janine Kirstein, Krzysztof Liberek,  Dejana Mokranjac, Nadinath Nillegoda, Carlos Ramos, Mathieu Rebeaud, David Ron, Sabine Rospert, Chandan Sahi, Reut Shalgi, Bartlomiej Tomiczek, Ryo Ushioda, Elizaveta Ustyantseva, Yihong Ye, Maciej Zylicz, Harm H. Kampinga. (2024). J-domain proteins: From molecular mechanisms to diseases. Cell Stress and Chaperones. 2024.

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• Sweeney KM, Chantarawong S, Barbieri EM, Portz B, Copley K, Lapidot T, Cajka G, Duhamel L, Greenwald P, Spruce L, Fazelinia H, Saida N, Shalgi R, Shorter J, Shalem O. CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. PLoS Genetics. 2024.

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• Hadar S.*, Meller, A.*, Saida, N., and Shalgi, R. Stress-induced transcriptional readthrough into neighboring genes is linked to intron retention. iScience. 2022. *Equal contribution. PDF

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• Rozales K*, Younis A*, Saida N, Meller A, Goldman H, Kellerman L, Heinrich R, Berlin S, Shalgi R. Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens. Nature Communications . 2022. *Equal contribution. PDF

  • ​Picked to feature in the Editor’s Highlights page of Nature Communications.

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• Kane, O., McCoya, M., Jada, R., Borisovc, V., Zag, L., Zag, A., Schragenheim-Rozales, K., Shalgi, R., Levy, NS., Levy, AP., Marsh, ED. Characterization of spontaneous seizures and EEG abnormalities in a mouse model of the human A350V IQSEC2 mutation and identification of a possible target for precision medicine based therapy. Epilepsy Research. 2022.

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• Jada, R., Zag, L., Borisov, V., Levy, NS., Netser, S., Jabarin, R., Wagner, S., Schragenheim-Rozales, K., Shalgi, R., Levy, AP.  Housing of A350V IQSEC2 pups at 37 degrees C ambient temperature prevents seizures and permits the development of social vocalizations in adulthood. Int J Hyperthermia  . 2021. 

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• Meller, A. and Shalgi R. The aging proteostasis decline: From nematode to human. Experimental Cell Research. 2021. PDF. 

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• Sabath, N.*, Levy-Adam, F.*, Younis, A.*, Rozales, K., Meller, A., Hadar, S., Soueid-Baumgarten, S., Shalgi, R. Cellular proteostasis decline in human senescence. PNAS. 2020 . PDF. *Equal contribution.

  • ​Highlighted in Communications Biology.

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• Nir Gonen#, Anatoly Meller#, Niv Sabath and Reut Shalgi. Amino acid biosynthesis regulation during ER stress is coupled to protein expression demands. iScience. 2019 . PDF . # These authors contributed equally to the work.

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• Nir Gonen, Niv Sabath, Christopher B. Burge, and Reut Shalgi. Widespread PERK-dependent repression of ER targets in response to ER stress. Scientific Reports​. 2019 . PDF

  • ​Featured in “Top 100 Cell and Molecular Biology”, 2019

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• Eli Rogers*, Reem Jada*, Kinneret Schragenheim-Rozales*, Megha Sah, Marisol Cortes, Matthew Florence, Nina Levy, Rachel Embrey Moss, Randall Walikonis, Raz Palty, Reut Shalgi, Daniela Lichtman, Alexandra Kavushansky, Nashaat Z. Gerges, Itamar Kahn, George Kwabena Essien Umanah, Andrew Peter Levy. An IQSEC2 mutation associated with intellectual disability and autism results in decreased surface AMPA receptors.  Frontiers in Molecular Neuroscience. 2019 . *These authors contributed equally to the work.                                           

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• Yuval Wiesel, Niv Sabath and Reut Shalgi. DoGFinder: a software for the discovery and quantification of readthrough transcripts from RNA-seq. BMC Genomics, 2018 . PDF.

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• Anna Vilborg, Niv Sabath, Yuval Weisel, Jenny Nathans, Flonia Levi-Adam, Therese A. Yario, Joan A. Steitz, and Reut Shalgi. Comparative analysis reveals genomic features of stress-induced transcriptional readthrough. PNAS, 2017 . PDF.

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• Reut Shalgi, Jessica A Hurt, Susan Lindquist and Christopher B Burge. Widespread Inhibition of Posttranscriptional Splicing Shapes the Cellular Transcriptome following Heat Shock. Cell Reports, 2014, June. Pubmed. PDF.

  • Featured in Nature Reviews Molecular Cell Biology: Heat Stresses Splicing, 2014 .

 

• Reut Shalgi, Jessica A Hurt, Irina Krykbaeva, Mikko Taipale, Susan Lindquist and Christopher B Burge. Widespread regulation of translation by elongation pausing in heat shock. Molecular Cell, 2013 Feb. 

• Featured in Nature SMB: Stressed ribosomes take the slow road, 2013 .

• Featured in Nature Reviews Genetics: Gene regulation: Global translational pausing in response to stress, 2013 Feb.

 

• Dvir Dahary*, Reut Shalgi* and Yitzhak Pilpel. A likely evolutionary origin of microRNAs in animals. Mol Biol Evol, 2011 May.

       * These authors equally contributed to this work

 

• Reut Shalgi, Yitzhak Pilpel and Moshe Oren. Repression of transposable-elements – A miRNA anti-cancer defense mechanism. Trends in Genetics, 2010 Jun.

 

• Roi Avraham, Aldema Sas-Chen, Ohad Manor, Israel Steinfeld, Reut Shalgi, Gabi Tarcic, Ido Amit, Gad Getz, Anne-Lise Børresen-Dale, Yitzhak Pilpel, Zohar Yakhini, Eran Segal and Yosef Yarden. EGF downregulates miRNAs that normally restrain oncogenic transcription factors. Sci Signal, 2010 Jun.

 

• Reut Shalgi, Ran Brosh, Moshe Oren, Yitzhak Pilpel, and Varda Rotter. Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate. Aging, 2009 Sept.

 

• Nanna R. Christoffersen, Reut Shalgi, Lisa B. Franke, Mikkel Klausen, Yitzhak Pilpel, Finn Cilius Nielsen, Moshe Oren and Anders H. Lund. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death and Differentiation, 2009 Aug.

 

• Ran Brosh*, Reut Shalgi*, Atar Liran, Gilad Landan, Katya Korotayev, Giang Nguyen, Espen Enerly, Hilde Johnsen, Yosef Buganim, Hilla Solomon, Ido Goldstein, Shalom Madar, Naomi Goldfinger, Anne-Lise Børresen-Dale, Doron Ginsberg, Curtis C. Harris, Yitzhak Pilpel, Moshe Oren and Varda Rotter. p53-repressed miRNAs are Involved with E2F in a Feed Forward Loop Promoting Proliferation. Molecular Systems Biology, 2008 Nov.

       *These authors contributed equally to this work.

 

• Reut Shalgi, Daniel Lieber, Moshe Oren and Yitzhak Pilpel, Global and local architecture of the mammalian microRNA-transcription factor regulatory network. PLoS Comp. Biol. 2007 Jul.

 

• Yaguang Xi, Reut Shalgi, Oystein Fodstad,Yitzhak Pilpel, and Jingfang Ju, Differentially Regulated Micro-RNAs and Actively Translated Messenger RNA Transcripts by Tumor Suppressor p53 in Colon Cancer. Clin Cancer Res. 2006 Apr.

 

• Reut Shalgi, Michal Lapidot, Ron Shamir and Yitzhak Pilpel, A catalog of stability-associated sequence elements in 3' UTRs of yeast mRNAs. Genome Biology 2005 Sep.