How do cells compartmentalize regulatory networks during stress?

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What is the link between RNA stress-regulation and pathological aggregation in ALS?

 

How do physiological condensates turn into pathological aggregate?

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Can we harness proteostasis regulation to fight pathological aggregation in ALS and Huntington's disease? 

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We take a systems biology approach to studying physiological and pathological condensates, and how proteostasis networks regulate them.

 

We combine molecular with computational biology and data science, and developing new screening approaches, including CRISPR and high content imaging screens to explore condensates in high resolution.  

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The lab is growing and we are recruiting!

Check out the Join the lab page.