The Shalgi Lab
How does a cell sense its own protein folding state?
How can a cell tune its protein levels when
proteins misfold or aggregate?
Can we rescue cells from neurodegeneration-related protein aggregation? YES WE CAN!
The human cell is a well-coordinated system.
In our lab we try to understand this coordination between
several cellular networks, how it works to maintain protein
homeostasis in the cell, and how it goes wrong in disease.
We are fascinated by the cross-talk between two crucial
systems in the cell, thus far mostly considered as separate:
Protein synthesis - primarily the ribosome, and
Protein folding - i.e. molecular chaperones
We are looking at networks of chaperones and co-chaperones
and their cross-talk with the translation machinery, and we are
interested in the way that molecular chaperones control translation during conditions of stress and neurodegeneration, including Huntington's disease and ALS.
We are using cutting-edge high-throughput technologies: ribosome footprinting and robotic LUMIER protein-protein interaction assays.
The lab is growing and we are recruiting!
Check out the Join the lab page.